You are discussing with your junoir the following antidote :
Q1.What are the common indications?
Q2.What are the recommended doses?
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You are discussing with your junoir the following antidote :
Q1.What are the common indications?
Q2.What are the recommended doses?
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Vitamin K 1 is an essential component factor in the hepatic synthesis of coagulation factors,II, VII, IX, and X.
Indications:
Excessive anticoagulations by warfarin and superwarfarin as evidenced by elevation prothrombin time
Vitamin K deficiency with coagulopathy
Hypoprothrombinemia resulting from salicylate overdose
Dosages and rout:
Oral : the usual dose is 10_50 mg 2 to 4 times per day for adult and 5_10 mg (0.4 mg/kg/per dose ) 2 to 4 times for children
Of note very high dose have been required for brodifacoum poisoning and for several weeks
Parenteral injection: not likely to be faster in reversal and associated with potential serious side effects( e.g anaphalactoid reactions .SC administration is preferred over IM.
The usual dose is 10 _25 mg in adult repeated 6 to 8 hours, children 1_5 mg
References:
Olsen's Poisoning and drug overdose, 6th edition